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Search Results for " oxidative damage "

44

抑制剂 & 化合物

37

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5116	Iprodione	Others; Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others
	Iprodione 是一种二甲酰亚胺类的高度特异性杀菌剂，能通过产生自由氧自由基引起氧化损伤。
T14042	4-P-PDOT 4-phenyl-2- propionamidotetralin	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	4-P-PDOT (4-phenyl-2- propionamidotetralin) 是一种选择性和亲和性的褪黑激素受体拮抗剂，可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。
T40192	dGTP 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dGTP（2'-Deoxyguanosine-5'-triphosphate）作为脱氧核糖核酸（DNA）合成的基本单元，属于鸟苷核苷酸，对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T1710	Trolox	Apoptosis; Antioxidant; Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Trolox 是一种维生素 E 的类似物，具有强大的抗氧化作用。它还是强大的膜损伤抑制剂。
T12059L	Mitoquinone mesylate MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Mitoquinone mesylate (MitoQ10 mesylate) 是可防止氧化损伤的抗氧化剂，靶向TPP 的线粒体。
T68182L	3-Hydroxykynurenamine HCl 3-OH-Kynurenamine HCl,3-Hydroxykynurenamine HCl（99362-47-7 Free base）	Others	Others
	3-Hydroxykynurenamine HCl (3-OH-Kynurenamine HCl) 是一种免疫调节生物胺，是氨基酸分解代谢的中间体，可诱导氧化损伤和促进细胞死亡。
T7511	Cyclo(his-pro)	NF-κB; Endogenous Metabolite	Metabolism; NF-κB
	Cyclo(his-pro) 是一种口服具有活力的，结构上与促甲状腺激素释放激素相关的环状二肽。它能够抑制NF-κB 核积累，也能够穿越脑血屏障并影响多种炎症和应激反应。
T64923	Sodium citrate Citrosodine,Natrocitral,柠檬酸钠	Others	Others
	Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。
T14991	CMS-121 CMS121	Acetyl-CoA Carboxylase	Metabolism
	CMS-121 是喹诺酮衍生物，对乙酰辅酶 A 羧化酶 1 具有抑制作用，具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性，EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎，抗氧化，神经保护和肾保护作用。
T13920L	Terlipressin Acetate Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素	Vasopressin Receptor	GPCR/G Protein
	Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂，对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
T80644	DNA polymerase-IN-1	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	DNA polymerase-IN-1 作为DNA聚合酶抑制剂，展现出对肿瘤细胞的抗增殖活性，其半抑制浓度（IC50）为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶，IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性，可用于研究氧化损伤和结直肠癌。
T27054	CMX-2043 LIPEA,LIP-EA,R-LIP-EA-OH
	CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.
T30035	Ampelopsin C
	Ampelopsin C protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway.
T35968	Nitrosobenzene
	Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils.
T22370	Mitoquinol mesylate	Others	Others
	Mitoquinol, a ubiquinone derivative, specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. Mitoquinol is an antioxidant, protecting mitochondria from oxidative damage and preventing lipid peroxidation-
T39795	Tricarbonyldichlororuthenium(II) dimer CORM-2
	Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.
T68884	Aplysin
	Aplysin is an antineoplastic agent. Aplysin has been shown to suppress breast cancer cell activity via inhibition of the PI3K/AKT/FOXO3a pathway. Aplysin has also been shown to protect hepatocytes against oxidative damage.
T28047	Mitoquinone-cyclodextrin MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin
	Mitoquinone-cyclodextrin is a 1:1 molar ratio complex of Mitoquinone mesylate with cyclodextrin. Mitoquinone mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage. M
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T78887	ROS-IN-2	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	ROS-IN-2 (compound 85) 为次狼烷三萜衍生物，具有抑制细胞内过量ROS及其他氧化应激源生成的作用，从而保护线粒体避免受损。该化合物在心肌缺血/再灌注（MI/R）损伤研究中具有潜在应用价值。
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T80207	Tetrapeptide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Tetrapeptide 作为α-MSH的类似物，能促进黑色素的合成；其通过降低活性氧化物质生成和提升DNA光产物修复效率，有效减轻DNA损伤。
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T81800	MHLWAAK
	MHLWAAK，抗氧化活性肽，源自C-藻蓝蛋白胰酶水解产物。该肽展现出显著DPPH及ABTS自由基清除效能，并能保护斑马鱼幼虫不受H2O2诱导的氧化损害。
T81828	MDYYFEER
	MDYYFEER 是源自 C-藻蓝蛋白胰酶水解产物的抗氧化活性肽，能有效清除 DPPH 及 ABTS 自由基，并能保护斑马鱼幼虫免受 H2O2 诱导的氧化损害。
T70978	5-Hydroxy Lansoprazole Sulfide
	5-Hydroxy Lansoprazole Sulfide is an inhibitor of fatty acid synthase (FASN). FASN, which is responsible for de-novo synthesis of lipids, has been found to be overexpressed in cancerous tissue. 5-Hydroxy Lansoprazole Sulfide specifically inhibits enoyl reductase, and was found to more effectively inhibit FASN function than lansoprazole and was also more efficient at regulating NHEJ repair of oxidative DNA damage via PARP1.
T75268	84-B10
	84-B10是一种3-苯基戊二酸衍生物，能够抑制cisplatin诱导的肾小管铁死亡，并减轻cisplatin引起的线粒体损伤和氧化应激，从而有效改善cisplatin诱导的急性肾损伤(AKI)。
T81799	MHLWAAK TFA
	MHLWAAK TFA是从C-藻蓝蛋白胰酶水解产物中分离的抗氧化活性肽。它展现出了较强的DPPH和ABTS自由基清除效应，并且能保护斑马鱼幼虫免遭H2O2引发的氧化伤害。
T81827	MDYYFEER TFA
	MDYYFEER TFA为从C-藻蓝蛋白胰酶水解产物中提取的抗氧化活性肽，展现了显著的DPPH与ABTS自由基清除效果，并能保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T81863	MAQAAEYYR TFA
	MAQAAEYYR TFA 是从 C-藻蓝蛋白胰酶水解产物中分离得到的一种具有高抗氧化活性的肽。它展现了显著的 DPPH 及 ABTS 自由基清除作用，并能有效保护斑马鱼幼虫不受 H2O2 诱导的氧化损伤。
T81864	MAQAAEYYR
	MAQAAEYYR 是从C-藻蓝蛋白的胰酶水解产物中分离得到的一种具备显著抗氧化活性的肽。它在DPPH和ABTS自由基清除实验中显示出较高的效率，并能有效保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T78071	3-Methylglutaconic acid β-Methylglutaconic acid	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	3-Methylglutaconic acid 是MGTA (3-甲基戊二酸尿症) 的主要积累代谢物，能够诱发脂质和蛋白质的氧化损伤，减弱大脑皮层上清液的非酶促抗氧化防御，导致氧化应激。此化合物适用于研究大脑损伤相关疾病。
T35996	FeTPPS
	Peroxynitrite is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.[1] FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo. The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 &#181M). [2][3] FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles...
T60489	hMAO-B/MB-COMT-IN-1
	hMAO-B/MB-COMT-IN-1 是 MAO-B/MB-COMT 的双重抑制剂，对 hMAO-B 的IC50值为 2.5 μM，对MB-COMT 的IC50值为 3.84 μM。hMAO-B/MB-COMT-IN-1 能保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD)等的研究。
T62062	MAO-B-IN-7
	MAO-B-IN-7 是有效的、具有血脑屏障渗透性的MAO-B 和AChE 抑制剂。MAO-B-IN-7抑制人 AChE、电鳗 AChE 和 MAO-B 的IC50分别为 41 nM、87 nM 和 0.3 μM。MAO-B-IN-7 可以有效缓解氧化应激和神经炎症损伤。
T33631	Neocuproine Neocuproin
	Neocuproine 是一种铜（I）螯合剂，可增强电场刺激引起的输精管收缩的嘌呤能成分，常被用作配位试剂和铜离子检测剂。Neocuproine 与铜离子形成稳定的络合物，并可在某些化学反应和分析方法中起到催化作用。Neocuproine 作为铁和钴上的氧化还原活性配体平台，对NSC34细胞氧化损伤的保护作用。
T60658	hMAO-B/MB-COMT-IN-2
	hMAO-B/MB-COMT-IN-2 是MAO-B/MB-COMT 的双重抑制剂，对hMAO-B 和MB-COMT 的IC50值分别为 4.27 μM 和 2.69 μM。hMAO-B/MB-COMT-IN-2 保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD) 等的研究。
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta...
T73912	Maysin
	Maysin 是一种具有神经保护作用的 C-糖基黄酮，可以从玉米须中分离得到。Maysin 对 Syn 淀粉样蛋白聚集体-低聚物和原纤维引起的损伤具有保护作用。Maysin 可防止氧化应激和细胞内钙稳态失衡，激活自噬降解过程。Maysin 可用于帕金森病(PD) 的研究。
T73558	W1131
	W1131 是一种有效的STAT3抑制剂，可引发铁死亡。W1131 在胃癌皮下异种移植模型、类器官模型和 PDX 模型中抑制癌症进展。W1131 有效减轻癌细胞对 5-FU 化学耐药性。W1131 调节细胞周期、DNA 损伤反应和氧化磷酸化，包括IL6-JAK-STAT3通路和铁死亡 (ferroptosis) 通路。
T80847	W1131 TFA	STAT	JAK/STAT signaling; Stem Cells
	W1131 TFA 是一种抑制STAT3并诱导铁死亡(ferroptosis)的有效化合物。在胃癌的皮下异种移植模型、类器官模型以及PDX模型中，它都能显著阻止疾病的发展。此外，W1131能有效缓解癌细胞对5-FU的化学耐药性。该化合物还通过调节IL6-JAK-STAT3和铁死亡(ferroptosis)通路来影响细胞周期、DNA损伤响应和氧化磷酸化过程。
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...

化合物

Cat.No: T5116

Target: Others, Reactive Oxygen Species, Antifungal

Cat.No: T14042

Synonym: 4-phenyl-2- propionamidotetralin

Target: Melatonin Receptor, MT Receptor

Cat.No: T40192

Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T1710

Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species

Mitoquinone mesylate

Cat.No: T12059L

Synonym: MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate

Target: Reactive Oxygen Species

3-Hydroxykynurenamine HCl

Cat.No: T68182L

Synonym: 3-OH-Kynurenamine HCl,3-Hydroxykynurenamine HCl（99362-47-7 Free base）

Target: Others

Cat.No: T7511

Target: NF-κB, Endogenous Metabolite

Cat.No: T64923

Synonym: Citrosodine,Natrocitral,柠檬酸钠

Target: Others

Cat.No: T14991

Synonym: CMS121

Target: Acetyl-CoA Carboxylase

Terlipressin Acetate

Cat.No: T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素

Target: Vasopressin Receptor

DNA polymerase-IN-1

Cat.No: T80644

Target: Antiviral, DNA/RNA Synthesis

Cat.No: T27054

Synonym: LIPEA,LIP-EA,R-LIP-EA-OH

Cat.No: T30035

Cat.No: T35968

Mitoquinol mesylate

Cat.No: T22370

Target: Others

Tricarbonyldichlororuthenium(II) dimer

Cat.No: T39795

Synonym: CORM-2

Cat.No: T68884

Mitoquinone-cyclodextrin

Cat.No: T28047

Synonym: MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin

Kahweol linoleate

Cat.No: T71480

Cat.No: T78887

Target: Reactive Oxygen Species

Cat.No: T71479

Cat.No: T80207

Target: DNA/RNA Synthesis

Kahweol stearate

Cat.No: T71478

Kahweol Acetate

Cat.No: T68641

Kahweol palmitate

Cat.No: T68642

Cat.No: T81800

Cat.No: T81828

5-Hydroxy Lansoprazole Sulfide

Cat.No: T70978

Cat.No: T75268

Cat.No: T81799

Cat.No: T81827

Cat.No: T81863

Cat.No: T81864

3-Methylglutaconic acid

Cat.No: T78071

Synonym: β-Methylglutaconic acid

Target: GABA Receptor

Cat.No: T35996

hMAO-B/MB-COMT-IN-1

Cat.No: T60489

Cat.No: T62062

Cat.No: T33631

Synonym: Neocuproin

hMAO-B/MB-COMT-IN-2

Cat.No: T60658

6(5H)-Phenanthridinone

Cat.No: T72017

Cat.No: T73912

Cat.No: T73558

Cat.No: T80847

Target: STAT

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

Cat. No.	Product Name	Target	Signaling Pathways
TN2100	Pratensein 红车轴草素,三叶草	Others; NF-κB	NF-κB; Others
	Pratensein 是黄酮类化合物，能够减少氧化损伤和恢复突触和 BDNF 水平，改善 β-淀粉样蛋白诱导的大鼠认知障碍。
T5669	Citric acid monohydrate	Others	Others
	Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T20793	Magnesium Lithospermate B 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B	Others	Others
	Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物，从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。
T8177	Galactinol	Others	Others
	Galactinol Hydrate 清除羟基自由基并保护植物细胞免受氧化损伤。
T19165	8-Hydroxyguanine 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine	Endogenous Metabolite	Metabolism
	8-Hydroxyguanine (8 Hydroxyguanine)是由活性氧物质产生的主要诱变前损伤。它导致G-T和A-C置换。8-Hydroxyguanine 是一种 RNA 氧化和 DNA 氧化损伤的生物标记物。8-Hydroxyguanine 具有致突变性和致癌性，常用于癌症实验中。
T2S2003	Phlorizin dihydrate 根皮苷,Phloridzin dihydrate,弗罗利辛二水合物	Others	Others
	Phlorizin dihydrate (Phloridzin dihydrate) 能显着抑制氧化性DNA 损伤。
TQ0154	8-Hydroxyguanosine	Others; Endogenous Metabolite	Metabolism; Others
	8-Hydroxyguanosine 是氧化应激的系统标记，也是氢氧自由基对 RNA 损伤的标记。
TN1461	(-)-Butin Butin,漆黄素 ( 紫铆素)	Akt; PI3K; Nrf2	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。
T3671	Vitexin-2"-O-rhamnoside 牡荆素鼠李糖苷,牡荆素-2-O-鼠李糖苷,2''-O-Rhamnosylvitexin,Vitexin-2-O-rhaMnoside,Vitexin-2''-O-rhamnoside,Apigenin-8-C-glucoside	Others	Others
	Vitexin-2"-O-rhamnoside (Apigenin-8-C-glucoside) 是一种黄酮苷类化合物，存在于Cratagus pinnatifidaBge 中，对 H2O2介导的氧化应激损伤具有保护作用，可用于研究心血管系统疾病。
T1695	DL-O-Tyrosine	Amino Acids and Derivatives	Metabolism
	DL-O-Tyrosine 是苯丙氨酸的代谢物，是形成儿茶酚胺的前体。它被用作β-地中海贫血中蛋白质氧化损伤的生物标志物。
T4890	3-Nitro-L-tyrosine 3-Nitrotyrosine,3-硝基-L-酪氨酸	Endogenous Metabolite	Metabolism
	3-Nitro-L-tyrosine (3-Nitrotyrosine) 在系统自免疫原性条件下，能够作无氮自由基修饰蛋白的生物标记物。
TN1043	Keracyanin chloride Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride,花青素鼠李葡糖苷	COX	Immunology/Inflammation; Neuroscience
	Keracyanin chloride (Cyanidin 3-rutinoside chloride) 是一种花青素，能够抑制氧化的小牛胸腺 DNA 中丙二醛的形成，具有抗氧化作用。
TN7134	Magnoloside B	Glucosidase	Metabolism
	Magnoloside B 是一种来自木兰果实的苯乙醇糖苷，是一种 α-glucosidase 抑制剂，对自由基诱导的氧化损伤的保护作用，可用于研究癌症。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T2S1008	Oxysophoridine Sophoridine N-oxide,氧化槐定碱	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱，具有抗发炎，抗氧化应激和抗凋亡的作用。
T3008	Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌	Apoptosis; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的，有抗真菌和抗菌活性。
T5255	5-Hydroxymethyluracil 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine	Others; Endogenous Metabolite	Metabolism; Others
	5-Hydroxymethyluracil (a-Hydroxythymine) 是一种氧化性 DNA 损伤的产物，能够增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。
TN1831	Macranthoside A Kalopanaxsaponin H	Antioxidant	oxidation-reduction
	Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷，属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性，抑制促炎细胞因子的产生和抑制炎症信号通路的激活，有助于中和有害的自由基，保护细胞免受氧化损伤，可以促进神经元的存活和生长，并防止氧化应激或神经毒性化合物引起的神经元细胞死亡，具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
T3414	Morroniside 莫诺苷,奎宁树	Apoptosis; MMP; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用，可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
TN2082	Pinostrobin	Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Pinostrobin 是一种 PCSK9抑制剂，可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物，并具有抗氧化，抗炎，抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
TN2244	Sulfuretin 硫黄菊素	NF-κB; Autophagy	Autophagy; NF-κB
	Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂，IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。
T9279	nerolidol acetate	Others	Others
	Nerolidol acetate是一种具有抗癌、抗炎、抗菌和抗虫的活性的天然倍半萜。Nerolidol acetate可抑制寄生虫活动，抑制吸血虫病、线虫病以及疟疾等。Nerolidol acetate可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤，对小鼠海马神经细胞具有保护作用。
T3426	Bacoside A	MMP; Others; TNF; Dopamine Receptor; NOS; ROS	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidative stress by an increase in the concentration of antioxidant enzymes and sustain membrane integrity which leads to restoring the damage caused by tBHP. Bacoside A can able to inhibit the progression of Experimental Autoimmune Encephalomyelitis (EAE) may be by the inhibition of i...
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T24025	Eckol
	Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.
T10018	1-Methyladenine	Others	Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.
T9454	4-Hydroxyestrone	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-Hydroxyestrone 是一种内源性雌激素代谢物，可强烈保护神经元细胞免受氧化损伤。
T3490	alpha-(3,4-Dihydroxyphenyl)lactic acid	Antioxidant	oxidation-reduction
	alpha-(3,4-Dihydroxyphenyl)lactic acid 具有抗氧化活性，可通过 PI3K/Akt/Nrf2 信号通路增强 HO-1 表达以抑制 6-OHDA 诱导的氧化损伤。
TN1542	Cycloheterophyllin	NADPH-oxidase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.
TN3403	Djalonensone 交链孢霉甲基醚,Alternariol monomethyl ether	Immunology/Inflammation related	Immunology/Inflammation
	Djalonensone (Alternariol monomethyl ether) 具有强大的 DPPH 自由基清除作用。
T27711	Kahweol Eicosanate J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast
T75699	Coenzyme Q6
	Coenzyme Q6 (Ubiquinone 30)，一种异戊二烯化的苯醌脂质，主要在呼吸电子传输链中发挥作用，并作为脂质抗氧化剂，具备抗氧化性能，能够防止自由基生成和氧化损伤。
TN3323	Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性，通过激活PI5K/Akt信号传导，减轻体内大脑中动脉闭塞小鼠缺血性中风损伤，并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力，抑制线粒体膜电位 (MMOP) 崩溃，抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平，改善缺血性中风 (IS) 大鼠神经损伤。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: TN2100

Synonym: 红车轴草素,三叶草

Target: Others, NF-κB

Citric acid monohydrate

Cat.No: T5669

Target: Others

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Magnesium Lithospermate B

Cat.No: T20793

Synonym: 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B

Target: Others

Cat.No: T8177

Target: Others

8-Hydroxyguanine

Cat.No: T19165

Synonym: 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine

Target: Endogenous Metabolite

Phlorizin dihydrate

Cat.No: T2S2003

Synonym: 根皮苷,Phloridzin dihydrate,弗罗利辛二水合物

Target: Others

8-Hydroxyguanosine

Cat.No: TQ0154

Target: Others, Endogenous Metabolite

Cat.No: TN1461

Synonym: Butin,漆黄素 ( 紫铆素)

Target: Akt, PI3K, Nrf2

Vitexin-2"-O-rhamnoside

Cat.No: T3671

Synonym: 牡荆素鼠李糖苷,牡荆素-2-O-鼠李糖苷,2''-O-Rhamnosylvitexin,Vitexin-2-O-rhaMnoside,Vitexin-2''-O-rhamnoside,Apigenin-8-C-glucoside

Target: Others

Cat.No: T1695

Target: Amino Acids and Derivatives

3-Nitro-L-tyrosine

Cat.No: T4890

Synonym: 3-Nitrotyrosine,3-硝基-L-酪氨酸

Target: Endogenous Metabolite

Keracyanin chloride

Cat.No: TN1043

Synonym: Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride,花青素鼠李葡糖苷

Target: COX

Cat.No: TN7134

Target: Glucosidase

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Cat.No: T2S1008

Synonym: Sophoridine N-oxide,氧化槐定碱

Target: Apoptosis, Antioxidant

Lawsone methyl ether

Cat.No: T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌

Target: Apoptosis, Antibacterial, Antifungal

5-Hydroxymethyluracil

Cat.No: T5255

Synonym: 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Macranthoside A

Cat.No: TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Cat.No: T3414

Synonym: 莫诺苷,奎宁树

Target: Apoptosis, MMP, Pyroptosis

Cat.No: TN2082

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Cat.No: TN2244

Synonym: 硫黄菊素

Target: NF-κB, Autophagy

nerolidol acetate

Cat.No: T9279

Target: Others

Cat.No: T3426

Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Cat.No: T6S2099

Target: Antioxidant, TNF

Cat.No: T24025

1-Methyladenine

Cat.No: T10018

Target: Others

4-Hydroxyestrone

Cat.No: T9454

Target: Estrogen Receptor/ERR, Endogenous Metabolite

alpha-(3,4-Dihydroxyphenyl)lactic acid

Cat.No: T3490

Target: Antioxidant

Cycloheterophyllin

Cat.No: TN1542

Target: NADPH-oxidase, PKA, PKC

Cat.No: TN3403

Synonym: 交链孢霉甲基醚,Alternariol monomethyl ether

Target: Immunology/Inflammation related

Kahweol Eicosanate

Cat.No: T27711

Synonym: J002075,J 002075,J-002075

Cat.No: T75699

Monomethyl lithospermate

Cat.No: TN3323

Synonym: Lithospermic acid monomethyl ester

Target: Akt, PI3K

Cat.No: T35624

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